3D animation as a tool for integrative modeling of dynamic molecular mechanisms.
Riggi M, Torrez RM, Iwasa JH.
Structure. 2024 Feb 1;32(2):122-130. doi: 10.1016/j.str.2023.12.007. Epub 2024 Jan 5. PMID: 38183978 Review.
SnapShot: Eukaryotic ribosome biogenesis II.
Hurt E, Iwasa J, Beckmann R.
Cell. 2024 Feb 29;187(5):1314-1314.e1. doi: 10.1016/j.cell.2024.01.043. PMID: 38428399
3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen Encephalitozoon intestinalis.
Antao NV, Lam C, Davydov A, Riggi M, Sall J, Petzold C, Liang FX, Iwasa JH, Ekiert DC, Bhabha G.
Nat Commun. 2023 Nov 23;14(1):7662. doi: 10.1038/s41467-023-43215-0. PMID: 3799643
Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller.
Wang S, Sass MI, Kwon Y, Ludlam WG, Smith TM, Carter EJ, Gladden NE, Riggi M, Iwasa JH, Willardson BM, Shen PS.
Mol Cell. 2023 Nov 2;83(21):3852-3868.e6. doi: 10.1016/j.molcel.2023.09.032. Epub 2023 Oct 17. PMID: 37852256
Macromolecular condensation buffers intracellular water potential.
Watson JL, Seinkmane E, Styles CT, Mihut A, Krüger LK, McNally KE, Planelles-Herrero VJ, Dudek M, McCall PM, Barbiero S, Vanden Oever M, Peak-Chew SY, Porebski BT, Zeng A, Rzechorzek NM, Wong DCS, Beale AD, Stangherlin A, Riggi M, Iwasa J, Morf J, Miliotis C, Guna A, Inglis AJ, Brugués J, Voorhees RM, Chambers JE, Meng QJ, O'Neill JS, Edgar RS, Derivery E.
Nature. 2023 Nov;623(7988):842-852. doi: 10.1038/s41586-023-06626-z. Epub 2023 Oct 18. PMID: 37853127
Depicting a cellular space occupied by condensates.
Liu D, Riggi M, Lee HO, Currie SL, Goodsell DS, Iwasa JH, Rog O.
Mol Biol Cell. 2023 Sep 1;34(10):tp2. doi: 10.1091/mbc.E22-11-0519.PMID: 37590933.
An educational visual resource to support understanding of liquid-liquid phase separation.
Riggi M, Iwasa JH.
Biochem Mol Biol Edu. 2023 Jul 14. doi: 10.1002/bmb.21766.
SnapShot: Eukaryotic ribosome biogenesis I.
Hurt E, Cheng J, Bassler J, Iwasa J, Beckmann R.
Cell. 2023; 186(10):2282-2282.e1. doi: 10.1016/j.cell.2023.04.030.
Communicating science through visual means.
Lyall K, Iwasa JH, Goodsell DS, Holt L.
Trends Biochem Sci. 2023 Jan;48(1):2-4. doi: 10.1016/j.tibs.2022.08.005.
The dawn of interoperating spatial models in cell biology.
Iwasa JH, Lyons B, Johnson GT.
Curr Opin Biotechnol. 2022 Dec;78:102838. doi: 10.1016/j.copbio.2022.102838. Epub 2022 Nov 16.PMID: 3640209
A new tool for annotating scientific animations and supporting scientific dialogue.
Liu H, Riggi M, Rogers J, Meyer M, Iwasa JH.
PLoS Biol. 2022 Aug 4;20(8):e3001731. doi: 10.1371/journal.pbio.3001731. eCollection 2022 Aug.
Dynamin is primed at endocytic sites for ultrafast endocytosis.
Imoto Y, Raychaudhuri S, Ma Y, Fenske P, Sandoval E, Itoh K, Blumrich EM, Matsubayashi HT, Mamer L, Zarebidaki F, Söhl-Kielczynski B, Trimbuch T, Nayak S, Iwasa JH, Liu J, Wu B, Ha T, Inoue T, Jorgensen EM, Cousin MA, Rosenmund C, Watanabe S.
Neuron. 2022 Sep 7;110(17):2815-2835.e13. doi: 10.1016/j.neuron.2022.06.010. Epub 2022 Jul 8.
The Mediator complex as a master regulator of transcription by RNA polymerase II.
Richter WF, Nayak S, Iwasa J, Taatjes DJ.
Nat Rev Mol Cell Biol. 2022 Jun 20:1-18. doi: 10.1038/s41580-022-00498-3.
Plant cytokinesis and the construction of new cell wall.
Sinclair R, Hsu G, Davis D, Chang M, Rosquete M, Iwasa JH, Drakakaki G.
FEBS Lett. 2022 Sep;596(17):2243-2255. doi: 10.1002/1873-3468.14426. Epub 2022 Jul 15.
The Simularium Viewer: an interactive online tool for sharing spatiotemporal biological models.
Lyons B, Isaac E, Choi NH, Do TP, Domingus J, Iwasa J, Leonard A, Riel-Mehan M, Rodgers E, Schaefbauer L, Toloudis D, Waltner O, Wilhelm L, Johnson GT.
Nat Methods. 2022 May;19(5):513-515. doi: 10.1038/s41592-022-01442-1.
Using animation to mediate scientific discourse.
Iwasa JH.
Nat Microbiol. 2022 Jan;7(1):3. doi: 10.1038/s41564-021-01024-5.
SynapsEM: Computer-Assisted Synapse Morphometry.
Watanabe S, Davis MW, Kusick GF, Iwasa J, Jorgensen EM.
Front Synaptic Neurosci. 2020 Dec 18;12:584549. doi: 10.3389/fnsyn.2020.584549. eCollection 2020.
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.
Rimel JK, Poss ZC, Erickson B, Maas ZL, Ebmeier CC, Johnson JL, Decker TM, Yaron TM, Bradley MJ, Hamman KB, Hu S, Malojcic G, Marineau JJ, White PW, Brault M, Tao L, DeRoy P, Clavette C, Nayak S, Damon LJ, Kaltheuner IH, Bunch H, Cantley LC, Geyer M, Iwasa J, Dowell RD, Bentley DL, Old WM, Taatjes DJ.
Genes Dev. 2020 Nov 1;34(21-22):1452-1473. doi: 10.1101/gad.341545.120. Epub 2020 Oct 15.
Using 3D Animation to Visualize Hypotheses.
Nayak S, Liu, H, Hsu, GI and Iwasa JH.
Trends Biochem Sci. 2020 May 15. doi: 10.1016/j.tibs.2020.04.009
Membrane constriction and thinning by sequential ESCRT-III polymerization.
Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR 3rd, Iwasa JH, Vershinin MD, Sundquist WI, Frost A.
Nat Struct Mol Biol. 2020 Apr;27(4):392-399. doi: 10.1038/s41594-020-0404-x. Epub 2020 Apr 6.
Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure.
Zhou CJ, Ji Y, Reynolds K, McMahon M, Garland MA, Zhang S, Sun B, Gu R, Islam M, Liu Y, Zhao T, Hsu G, Iwasa J.
Biochem Biophys Res Commun. 2020 Jun 4;526(3):647-653. doi: 10.1016/j.bbrc.2020.03.138. Epub 2020 Apr 2.
Preparing scientists for a visual future.
Nayak S, Iwasa JH.
EMBO Rep. 2019 Oct 14:e49347. doi: 10.15252/embr.201949347.
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Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS.
Science. 2019 Aug 2;365(6452):502-505. doi: 10.1126/science.aax0486. Epub 2019 Jun 27.
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP.
Elife. 2019 Jun 11;8. pii: e44071. doi: 10.7554/eLife.44071.
Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.
Andreotti AH, Joseph RE, Conley JM, Iwasa J, Berg LJ.
Annu Rev Immunol. 2018 Apr 26;36:549-578.
Dicer uses distinct modules for recognizing dsRNA termini.
Sinha NK, Iwasa J, Shen PS, Bass BL.
Science. 2018 Jan 19;359(6373):329-334. doi: 10.1126/science.aaq0921. Epub 2017 Dec 21.
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes.
Clapier CR, Iwasa J, Cairns BR, Peterson CL.
Nat Rev Mol Cell Biol. 2017 Jul;18(7):407-422. doi: 10.1038/nrm.2017.26. Epub 2017 May 17. Review.
Reverse-topology membrane scission by the ESCRT proteins.
Schöneberg J, Lee IH, Iwasa JH, Hurley JH.
Nat Rev Mol Cell Biol. 2017 Jan;18(1):5-17. doi: 10.1038/nrm.2016.121. Epub 2016 Oct 5. Review.
The Scientist as Illustrator.
Iwasa JH.
Trends Immunol. 2016 Apr;37(4):247-50. doi: 10.1016/j.it.2016.02.002. Epub 2016 Mar 9.
Architecture of the type IVa pilus machine.
Chang YW, Rettberg LA, Treuner-Lange A, Iwasa J, Søgaard-Andersen L, Jensen GJ.
Science. 2016 Mar 11;351(6278):aad2001. doi: 10.1126/science.aad2001. Epub 2016 Mar 10.
Bringing macromolecular machinery to life using 3D animation.
Iwasa JH.
Curr Opin Struct Biol. 2015 Apr;31:84-8.
Crafting a career in molecular animation.
Iwasa J.
Mol Biol Cell. 2014 Oct 1;25(19):2891-3.
The cell: an image library-CCDB: a curated repository of microscopy data.
Orloff DN, Iwasa JH, Martone ME, Ellisman MH, Kane CM.
Nucleic Acids Res. 2013 Jan;41(Database issue):D1241-50.
Animating the model figure.
Iwasa JH.
Trends Cell Biol. 2010 Dec;20(12):699-704.
Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments.
LeClaire LL 3rd, Baumgartner M, Iwasa JH, Mullins RD, Barber DL.
J Cell Biol. 2008 Aug 25;182(4):647-54. doi: 10.1083/jcb.200802145.
Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly.
Iwasa JH, Mullins RD.
Curr Biol. 2007 Mar 6;17(5):395-406.